cannot delete:access denied

I have run Ad Aware and Spybot and there are a few files that neither one can get rid of.  I have tried to remove them myself and it tells me "cannot delete:access denied". What can I do?

First you can give us some idea as to what the files are.  Does Adaware or spybot recommend any actions?

You can tell Ad-aware to start it's self before the rest of the programs load into the memory.

This will prevent ad/malware to be loaded into the memory.

Usually when Ad-aware cannot remove certain Ad/malware infections it will ask if it has to run at startup.

Press the settings button -> General -> Run at Windows Start Up