Well, I will give it a try. First of all I have taken apart and rebuilt minicomputers, but I have not done too well trained order parts and build something completely from scratch. There are just too many things that go wrong.
Here's the best advice I think I could give. Use a set of components that somebody else has already tried and proven to work. When you do high-performance high in stuff that gets to be an issue with compatibility. One of the problems is the power supply, you really have to be sure the power supply is appropriate for the equipment you have chosen.
Also, do you have some spare parts on hand for testing? Do the have the appropriate kind of tools? It's important to have very good quality hand tools for putting together the new machine. You make a slip with a screwdriver and you could scratch something very bad. If it was part of the motherboard, you're in deep trouble. So make sure the tools you have are the right kind for the job.
Also, if you run into something you don't understand, ask first before you turn on the power. Although commercial mass-produced computers have lots of safeguards built-in, that may not be true with a custom do-it-yourself computer. You hook up the wrong wire to the wrong place or if you forget something you could have bad results.
Yes, I know this sounds rather pessimistic. But I'm trying to help. You need to be prepared for something you didn't expect. Be very careful when handling the motherboard.
Hope you do a good job.