Optiplex 380 motherboard... If it lists the 9560 on its support listing then you should be all set. It should be a standard socket 775 CPU.
*You might need a better heatsink for the extra TDP heat that will be given off since the heatsink you started with is likely rated for 65 watts since the E7500 is a 65 watt TDP CPU and the new Core 2 Quad is a 95 watt TDP CPU.
Its also the kind of upgrade that will point out if you have a borderline power supply, so if it starts to acts funny after the CPU upgrade like failing to boot with black screen etc then you could be looking at needing a better power supply as well. If you already have a video card in it that is drawing heavy on the power supply the extra 30 watts of power consumption could be a tipping point to a non booting system or unstable system. If you have a better than stock power supply in it you should be all set but if its a 300 watt power supply you could find yourself needing a better power supply that can power the heavier power need.
