I'm having some crazy keyboard issues that are literally driving me mad. I had this issue a few months ago and I solved it by simply creating a new user in Vista. Essentially, whenever I open up a game, regardless of it being windowed or fullscreen, my keyboard bugs out. All my buttons are irresponsive unless I am holding shift, ctrl, or alt. To press "enter" I have to have my shift key pressed as well. The problem occured today while I was letting Mp3Gain adjust the volume of my Itunes library. I played a game of Prototype and left the house for a while, letting Mp3Gain run. When I came back and tried to play, the problem began. I honestly don't know what could have occured however if I can't solve the problem I'm doing a fresh install with 64 bit Vista, as I just recently upgraded from a Pentium D to a Core 2 Quad.
Specs:
Windows Vista Pro
MSI G33M Mobo
Intel Q5500 Core 2 Quad 3.15 GHz
Evga GTX260
2x1gb Patriot somethingorother, 2x1gb G.skill DDR2
Tagan BZ800 800w PSU