check the following:
This is probably what is stopping you from using Safe mode:
F2 - REG:system.ini: Shell=Explorer.exe logon.exe
userinit is a windows component; sdra64, on the other hand, is a trojan.
F2 - REG:system.ini: UserInit=D:\WINDOWS\system32\userinit.exe,D:\WINDOWS\system32\sdra64.exe,
this isn't necessarily a threat but there's no reason for it to be there:
O3 - Toolbar: (no name) - {CCC7A320-B3CA-4199-B1A6-9F516DD69829} - (no file)
"winupdate" is not a windows component. (windows update is performed by a process called wuaclt, if memory serves me)
O4 - HKLM\..\Run: [winupdate.exe] D:\WINDOWS\system32\winupdate.exe
O15 - Trusted Zone:
http://wow.allakhazam.comO20 - Winlogon Notify: yayyVMdc - yayyVMdc.dll (file missing)
and click "fix checked"
Also, try using the mbamrenamer tool,
here, or rename the malwarebytes shortcut and program file yourself, (as you have for hijackthis) and see if that let's you run it; or after fixing the items with hijackthis see if you can reboot into safe mode and run MBAM from there.