All depends on what you do with your computer;
If you just browse internet (most of times only well know sites like fb, gmail, ect ..) and you don't install unknown software to test them out. You are pretty secure with Microsoft's Security Essentials and Windows Defender.
And if you need to more control of your PC like firewall, application control, parent control or you are a use who browser suspicious web sites, installs everything you get you must go for a Internet Security suite which probably be Kaspersky.
For a Beginner or intermediate user of internet and computer MSE + Defender + All windows updates will do..
What ever you use, need to update regular and don't forget about OS updates too.
For you I would suggest MSE and remember to scan flash drives manually..