I once purchased a U3 drive from school. The first thing I did on it was remove U3.
IMO it's a pointless application that slows down the drive, and the computer.
What ever happened to plug and play? Now it's plug, wait for it to install and then play.
There was one time I unplugged my friends U3 device and I set the computer to stand by.
About 20 minutes later at home, I took out my laptop to find it hadn't gone to stand by. It had a BSOD, and the laptop was severely overheating.