Wouldn't having spyware make you think you were hacked? The repairman my mom called when the lock message came up, when he brought computer back said found spyware on it. The other weird thing we didn't understand was when he said someone named Amy locked the computer. Since I'm the only one who uses the computer.
Currently my brother-in-law who knows alot on computers and deals with the computer problems him and my sister have with their computer, is helping me with instructions on here and stuff, but haven't got a chance to do the Combofix thing, but he did put a bunch of different things on mine and mom's computer(hers is also having a bunch of problems too). Installed things like Ccleaner, that Malwarebytes thing, ATF cleaner, Spybot Search & Destroy, Ad-aware SE Personal, and a few other things- Spywareblaster, cwshredder. We have AVG on our computers too. Of course we are also trying to understand now how to use all these things. It's really confusing and have to make sure we don't make a mistake and accidently delete something important.
I don't even know how to do that Safe Mode thing you mentioned. We can get in it, but don't know what to do after getting in it. Like what to do to fix the computer the steps to do. That's why I need someone who knows what to do to do that type of stuff or walk me through it.