If you download or store significant numbers of archives (zip, rar, 7z etc) then you probably should enable it. As for making a "difference", then if you mean a difference in your computer's performance, or the time taken to do an antivirus scan, I should say it would not make much difference at all, and I'd be surprised if you noticed any change. Of course, if you had malware inside an archive, and the AV found it, that would be a big difference which you had achieved. (the difference between finding and not finding a virus). Try it and see how you get on.
