ccleaner has nothing to do with system security.
You need a good AV (NOD is fine I guess) and either MalwaerBytes or SuperAntiSpyware (or both - the free versions). I also use SpywareBlaster. And of course the most important facet of security is smart computing (don't open links or attachments in emails unless you are certain you know what they are, don't download anything unless you are 100% certain it is safe, etc).