I found this information and troubleshooting steps from the knowledge base. I'm not sure if you've tried it, I got some hits to other posts that may have been you, so I apologize if I'm leading you in circles
Error codes “0x80070643” or “0x643” occur when you install the .NET Framework updates.
Some 'generic' stuff you could give a go, though- you could try running sfc /scannow in the run dialog (Windows Key+R). This could fix any issues with the Windows Installer Database which could be causing these sorts of issues.
Another thing to try is uninstalling every .NET Framework version, then install the version you need for the software you are trying to run. One utility you can use for cleanup is the
dotnet Cleanup Tool, and remove all versions. Then you can install using the
standalone .NET 4.0 installer (to avoid possible issues from the standard web installer).
Unfortunately the error code the CLR gives (800040005) translates to a less than helpful "unspecified error", so there isn't a lot to go on. The error lists some log files that might have extra information on the problem if you can find and attach them to a post.