As far as I am concerned NONE of those utilities do anything to effect performance. I've tested them all - including TuneUp Utilities.
You probably have some issues with your system that we can help with. First, you say this has happened over time.
1) What is new or different since the last time everything worked properly (ie, new hw, new sw, virus, error, etc)?
2) What did you use to scan for malware?
3) What do you have running at boot? Have you tried a clean boot?
4) When was the last time you cleaned out the inside of the computer?