This can be caused by a couple of things.
My main suggestion for fixing this is to:
- Right click on the file you want to open, ie. "File.xlsx"
- Select "Open With..."
- Click on "Choose Program..."
- Click on "Microsoft Office Excel"
(If you do not see this option, click Browse, then locate "EXCEL.EXE" (Under C:\Program Files x86\Microsoft Office\Office12\excel.exe")) - Check mark "Always use the selected program to open this type of file"
- Click on "Ok"
If this is 32Bit windows you may not have a "Program Files x86" folder, so just replace that with "Program Files"
This should work to open those files from now on. However this could be a more serious problem, and you may want to get someone to look at your computer if you are not experienced with problems like this.