Thanks Guys,
The first thing I do when I have problems is to run full scans with my AV (MSSE), Malwarebytes, and Super Anti Spyware. Results are clean at this time. I also ran the Eset online scan as well.
As far as startups, I Do have a few running but they have been ongoing for some time now. Could all of the program updates be causing the problem? I am always having to update flash, java, MSSE, Firefox, IE, and of course the system. Could these programs be being written for the new multi core processors?
This general slowdown seems to be happening across several of my computers, both laptops and desktops. This slowdown seems to be most pronounced when online.