As long as you have positive and negative pressure airflow you have one fan that sucks in from say the front of the computer cool air and warm air is blown out the rear of it you should be fine. One thing I like to do with gaming setups is add a side panel fan that adds to the positive airflow inside the case drawing cool air through the side panel to have 2 fans drawing in cool air and the power supply has a fan and the rear of the case has a fan that are acting as the exhaust of the warm air.
Only drawback to more fans and more airflow is that you will have to clean it more often!!! Mainly just keep an eye on dust bunny build up and remove it from parts when it starts to accumulate. The quality and how fast it builds up depends on the environment that the computer is run in. If very clean it will take longer to get dirty inside at outside at the fans air entry points. But if you have cats, dogs, and forced hot air or central air system that is always floating dust around in the home then it will get dirtier quicker.