Implore my remark about a 32 bit version.
Cam you isolate the problem?
You said it does perform better in safe mode.
You say apps take long to load.
Have you done a check disk recently?
Run Check Disk from the Command Line to Find and Fix Errors. You can run Check Disk from the command line or within other utilities. At a command prompt, you can test the integrity of the E drive by typing the following command: chkdsk E:Or for the main drive: chkdsk C:
If this takes a long time, you may have some issues with eh hard drive.
(On my PC it can take over a minute.
)