This is a SmitFraud infection. You need to run
SmitRem.
Save it on your desktop or somewhere that you can find it. Run the archive and it will create a folder called SmitRem. Do nothing yet!
Reboot to safe mode, navigate to the SmitRem folder and double click
RunThis.bat.
A series of informational screens wll follow. Read each and press a key to continue.
Now the cleanup operation will begin. Any uninstallers for rogue programs will be initiated so follow the uninstall procedure.
After any rogue programs are uninstalled, the disk cleanup wizard will begin. Allow this to run it's full course.
Once done you should be able to reboot normally and free of any Smitfraud infection. A log file will be saved to c:\smitfiles.txt.
You should still check for other infections though. These things seldom seem to be unaccompanied.