Thank you to the person who took the time to reply.
Unfortunately, I wasn't very clear. I bought the computer in July 2006 from my work and the OS was already installed. I added some peripherals around the same time (DLINK broadband modem, mic, speakers, and external hard drive), and printer (HP All in one). I do not have any other disks than the OS and some of the software I was also given. I do not know enough about computers, motherboards/drivers to attempt to reinstall correctly.
I use the computer for the same thing(s) day in/out, I am used to what it does on a daily basis. I mentioned that I downloaded a program, can't remember what it was or where I downloaded it from, and have since deleted it, but this popup started around the same time I downloaded the program.I used Webroot and scanned for ad/spyware-none found. I have deleted/uninstalled this PCI Serial Port from the hardware profile, it keeps coming back. lol...like bad food.
Anyone else with a suggestion? Please "dumb it down" for me, that's why I came to you, because you know what to do....Thank you.