You could try the following :-
Boot with a MS-DOS Floppy or CD and try and press the alphabet that is giving a problem. If the problem persists, it is possible that your Keyboard has a problem - in this case try to get the keyboard repaired or replaced.
If on booting with the floppy or CD in the DOS mode, the keyboard works OK, then there is a problem with your Windows Operating System.
Install windows again and it should be OK.