Power supply would shut itself off. Found intermittent internal fan failure. Fixed with external fan wired to stock fan power wires. Ugly but effective enough to get a new one en route.
Memory failures. Multiple symptoms, would even pass memtest overnight. 2GIGS OCZ PC8500 overclocked using embedded SLI instructions to run at 1067 MHz. Tons of cooling, replaced with 2 Gigs Pony PC6500 @ 800MHz. Funny thing. The replacement OCZ memory would not run reliably either. Have had no real problems with my pony memory.
EVGA Nvidia 680i series Mobo. Poorly assembled motherboard, not enough heat sink in some spots, too much in others. Had to RMA the original mobo for numerous boot codes associated with the memory controller. This could have been the source of my memory problems but I think I had multiple defective parts as my pony memory wouldn't work in the other mobo, but works great in my "new" one.
Mouse and keyboard die all the time from all the Quake, Doom and UT , Farcry,Crysis ect, I punish them with. Rollerball mice rule...NOT
Other. Bill gates has managed to design an OS that despite my best efforts I have to reload at least once a year to keep running as smoothly as one would expect given how much I paid for it. You did pay for yours..right?