wrinklysteve...
If Crafty's suggestion does not work, try below...
What's the model number of your Epson Perfection Series scanner?
Have you tried going to Epson's site to download and install the latest software and/or drivers for this scanner?
Try this link:
Perfection SeriesSelect your scanner...then select your operating system. You'll be presented with a list of drivers, software, manuals, etc.
Reinstall the software...as you previously did. Then download and run the twain driver and scan utility from Epson. Save it to your desktop.
This self-extracting file contains the EPSON Scan Utility and TWAIN Driver for Windows Vista 32-bit and 64-bit Editions. This file self-extracts to your hard drive and is placed in a folder that begins with C:\EPSON\epson...
You will then need to update the driver...
Hopefully this will help...keep us posted.