The motherboard doesn't matter. What does is if the drive you want to move is SATA and your mobo doesn't have any SATA connections, or if the drive is ATA and your mobo doesn't have any ATA connections, you might have to get yourself a suitable adapter. Also, if the file system on the drive you want to move is NTFS you cannot access the files using Win.9n.
Apart from the foregoing moving hard drives around is easy, you could also consider getting a usb adapter and plugging up the drive as external.
Maybe you'd like to tell us what your hardware setup is, and which operating system is involved.
Good luck