All registry cleaners which are published by reputable, professional software companies are safe to run and will improve the performance of your computer. You can run them and safely delete/fix anything they find without checking it first.
Examples include Glary Utilities, Advanced WindowsCare, and Ashampoo WinOptimizer.
These are well-researched, thoroughly debugged, professional-grade products written with the corporate market in mind, and enterprise pays good money to use them. We are more fortunate because they are free for private use. YOU NEED HAVE NO FEAR OF THEM.
The statement that registry cleaners do not improve computer performance is incorrect. They don't do it by removing "registry bloat", because spurious registry entries will seldom or never exceed 1% of the total registry size anyway; they do it by removing entries which are "toxic" or dysfunctional.
Example: you might share a printer on a network. The printer is uninstalled while your terminal is powered down. When you reboot, your registry directs Windows to check up on the printer drivers. They can't be found, of course, but the search will continue until it times out, which may take a minute or longer. That's a minute extra on your boot time. Every time. There are a thousand examples of this kind which could be quoted, covering shutdown problems, stop errors, runtime errors, Shell32.dll errors...