I don't think it's a blacklist issue.
Nice article but I think he is a little off on a few points:
Ask yourself this: why don't Mac users run anti-virus software? Why don't UNIX users run anti-virus software? Because they don't need to.
It's because malware writers haven't put any effort into attacking a Mac. Too much work with no reward. But Mac viruses are rising, slowly but there new ones being released.
At its heart, anti-virus software is little more than a glorified blacklist. It maintains an internal list of evil applications and their unique byte signatures, and if it sees one on your system, kills it for you. Sure, anti-virus vendors will dazzle you with their ad copy, their heuristic this and statistical that; they'll tell you (with a straight face, even) that their software is far more than a simple blacklist. It's a blacklist with lipstick. It's the prettiest, shiniest, most kissable blacklist you've ever seen!
Not true. Behavior/heuristic detection is a very good resource. That's why users have to turn off their AV before using some of the specialized tools in malware removal. They behave just like some malware and will be terminated.
But hey, who am I to try and tell a programmer that software is better than something that can be done with DOS or manually.