I could be wrong, but this is what I think:
- less number of drives ( large number of drives can reduce the performance of HDD, for example C,D,E,F….L)
Generally true. If all of those partitions are on the same hard drive, it can lead to a reduction in speed of reading/writing. For example, copying data from a C: partition to a D: partition on the same hard drive means the drive can't read and write at the same time, it has to stop one to do the other. On two separate drives not sharing an IDE cable, it normally can read and write at the same time.
- Big volume of each disk drive (e.g. 500GB for c:\ )
If the question is does this make it perform any better, I don't believe so. Not that I've ever heard of anyway. Probably false.
- Creating partitions based on the number of cylinders and disks in HDD
Again, another idea I've never heard of. Would probably have to say it's false.
- Designing and tidying up files and folders somehow containing less files/folders in each subfolder.
Generally true. And defragmenting the hard drive regularly as well (especially after removing a lot of files) helps.
Other than that, everything Calum said which I won't bother repeating.