Are you abandoning the Comstar enclosure?
You are using this for data only?
Do you need more than 500GB?
Do you want both drives running all the time when the computer is on?
My experience is with RAID-1, only. I used it as the boot drives for a few months until I obtained a different computer which didn't have that capability. One drive started failing and was automatically being rebuilt every couple days. Didn't slow things down that much because RAID controller did all the work.
RAID-5 seems fine, but I believe RAID-1+0 would be good, too. Just don't use RAID-0.
http://en.wikipedia.org/wiki/RAIDSee section on Organization