This is a USB drive?
You might not want to use a USB hard drive. Instead, if you can, and if the external hard drive has it, use firewire as it allows more signal at once, therefor, faster response.
You should be able to disable the main drive in your BIOS if you cannot set up a boot order...
(Like Soybean said: If you disable your main drive, then you need to enable boot from USB)