You have NOD32 installed with Kaspersky? If both are running that would be a major slow down.
It's snooped NOD32 and found a hacker tool it's removed and quarantined. Just empty the quarantine of NOD32 or delete, if it's not wanted.
'xpkey.exe' and 'officekey.exe' retrieve your Product Key (cd key) from your registry, which can used for illegal purposes. It's snooping in a protected area, so it's warning you about it.
VNC is Virtual Network Computing, remote control software, which allows someone remotely to connect to your computer and access it as if they where viewing the screen, etc. Normally used for helping out people with computer troubleshooting, etc. However, it's a major hole in the security. Any remote access enabled allows easy hackers access as well.
mIRC is an old version and like I said before can be scripted for malicous activities and any old fool can be a server.
Entirely up to you what you want to keep, remove or update.
