Long time, no see, Wefro.
RAM: Yes, that RAM should be compatible with your board.
HDDs: Do you want to keep any data from the drive? If not, just boot from the Windows 10 install media, delete the partitions on the drive during setup to leave a clean drive to install to, and away you go. If you want to keep any data, the best way would be to back it up elsewhere - onto an external drive for example - and then do as above, just remove the partitions during setup. It's fairly straightforward to do but if you need any clarification, just say