I think deciding whether to run a PC 24/7 can depend on whether you have householder responsibilities like paying insurance premiums and power bills. My home fire insurance specifies unplugging non-essential electrical devices when on I'm away for more than 7 days. I don't think I could show, in the event of a fire caused by an unattended PC, that having it running was "essential".
More important, perhaps, is the cost of the power. My power company charges 0.12 UK pounds for one kilowatt-hour. My PC uses on average about 150 Watts. A powerful gaming PC might use 200 plus. If I keep it running 24/7 for a year, it will cost 157 pounds (assuming the price does not increase!). I am away at work 5 days a week for 10 hours a day, I sleep about 8 hours a night, and I have the PC on about 12 hours a day at weekends. I am away on vacation about 15 days a year. If I turn the PC off when I don't need it, I have calculated I save 113.62 pounds each year by not having it on 24/7. I would save the cost of my PC in 5.27 years. I have been running PCs like this for more than 20 years, and none of them have failed (as far as I know) because of not being left on 24/7. In fact after around 5.27 years, I genrally want to get a new one. Also, I think it's important to think about the planet.
I have seen that the average cost of one kWh is around 12 cents in the US, so those figures of mine work there too, using dollars instead of pounds.