HERE Tweak Windows to your heart's content.
Want to bend Windows to your will? Then you'll want to give RegToy a try. It lets you customize just about every aspect of how Windows works, from the taskbar and Start menu, to the Windows Explorer context menu, how your desktop and icons appear, and much more.
The number of settings you can change is astonishing. Vista users will particularly welcome it, because it gives you control over many Vista-specific features. In Vista, you can turn the Windows Mobility Center on and off, disable Windows error reporting, hiding the Control Panel, and much more.
Note that if you install this for Windows Vista, you'll have to install it as an administrator. And if you install it for XP, you'll have to download Microsoft .NET Framework 2.0.