It will require you to authenticate your key with them if it doesnt boot loop BSOD on you. Any major and sometimes minimal hardware changes will break the activation and require for it to be reactivated/authenticated again. Since you have a authentic windows 10 key or key based off the upgrade you should be all set.
I have only seen on very similar computer hardware builds where you can move a drive and have it not break the activation. But drastic hardware change is definitely going to break its activation.