Mouse cursor disappearing

[Little Marine]

Very frequently my mouse cursor is disappearing. Sometimes the cursor is there but won't move.   I have to reboot the computer to get it back. My computer is a desktop that was built by a friend of mine  3 years ago. It was a gaming computer. I had Windows 7 on it but upgraded to W10 earlier in the year. About  2 weeks ago there were some updates done automatically. The disappearing cursor started Sunday. I searched for this problem but the only thing I found were some programs to download to fix the problem. The mouse is USB hard wired.

[DaveLembke]

So when pointer disappears how do you navigate, does it come back when you move the mouse?

Have you tried installing a different mouse to see if its a mouse issue?

Have you scanned for virus's and come up clean?

Does anyone else have access to this system that may be trying to annoy you with a program running on this computer that hides the pointer to a far corner of screen and you lose mouse controls?  (There use to be a very annoying program to install to a friends computer called Drunk Mouse which made mouse controls offset and laggy, and so thats why I am asking if anyone planted anything on your system to play with you and frustrate you. These sort of programs exist to annoy. )
Aliases of Drunk.Mouse (AKA):
[Kaspersky]   not-virus:Joke.Win32.MovingMouse
http://www.exterminate-it.com/malpedia/remove-drunk-mouse

[Little Marine]

I replaced the mouse. Last night the cursor was on the screen but it wouldn't move. Also the keyboard will not work. I tried hitting the windows key to get the start menu up but it doesn't work. I have to turn the computer off and back on to get it to work. I ran a virus scan with nothing showing up. My wife is the only one with access to this computer. She surfs the net and does puzzles. I ran a malware scan but when it finishes I can't do anything because the computer is locked up.

[Lorraine walsh]

I would suggest you to restart the computer in clean boot mode and check if it helps. Also not quite sure, but have you checked that whether Mouse Driver in Windows 10 is compatible with your system?

[Little Marine]

The mouse has been working for at least 6 months on W10. What is clean boot mode?

[soybean]

It's not clean boot mode, it's safe mood.  See https://support.microsoft.com/en-us/help/12376/windows-10-start-your-pc-in-safe-mode

[Little Marine]

Thanks I will try safe mode tonight. I was looking this morning on how to get into safe mode in W10

[Little Marine]

The computer works in safe mode. I assume it would be a process of elimination to find out what is causing my problem. My question is where do I start?

[anthonyb5615]

Did u try using a different mouse? Or did u try reinstalling driver? Press window button then restart and hold shift key at exact same time to get into safe mode.

[Little Marine]

After having it safe mode it would take longer but it would do the same. I noticed in either mode the computer was locking up. I would have to reboot to get it to do anything. I did use a different mouse, updated the driver and went into safe mode. It still does the same thing.