Well if all the cables are together right, processor, memory, HDD, etc yes - but if this is a new drive probably not the way you expect it to... even if it is an old drive you have used before I doubt it will work right... you still need to install an O/S on the drive. This may entail logging into the motherboard's BIOS and enabling the boot devices so you can boot from your cd/dvd drive. Then drop your o/s install disk into the drive, fir the bad boy up and you're off.
D.