As far as detecting certain virus definitions, most of them are the same. I think the user interface is where people go separate ways.
I use AVG FREE, Spybot S&D(with the tea timer DISABLED!)...............However, if I suspect a virus on my system my strategy changes. I'll update definitions and scan with AVG, Spybot, Malwarebytes, and Kaspersky Online scanner. Once that is done, I'll post a Browser HiJacking log for some nerd to interpret for me
I'm sure I can learn to interpret them myself, but I don't want to delve too deep into security right now....I'm busy learning the varous functions of Windows, still.