The majority of all my Vista issue were driver / update related issues. Although honestly mostly driver issues. After the first few months I was able to fix most of my issues with drivers. Although some of them still encounter occasional hiccups, for the most part they work pretty good. I'm still primarily using XP though, I still have some big grudges on some of the things they've changed.
Like has been said earlier, I think Microsoft just released this OS too early and that many more of the small glitches still out there will be resolved with the SP and additional updates from vendors. Unlike other operating systems *nix / MacOS Microsoft has a lot of backward compatibility, new computer users, older software, and dozens of other small annoyances they would be so hard to deal with.