SMB may refer to any of the following:
2. SMB is short for system management bus.
3. Short for small and midsize business or small and medium-sized business, SMB is a description of a business with 100 or fewer employees. When compared with an enterprise, an SMB has different needs and abilities.
4. SMB is short for Super Mario Bros., an iconic video game developed for the NES (Nintendo Entertainment System). The first Super Mario Brothers game was released on September 13, 1985, in the United States.